Pharmacogenomics

Medical science today is at its pinnacle, offering better care options than ever before. In addition to superior diagnoses and treatment opportunities, this also includes the medication on the market. With the most FDA-approved drugs available in history, physicians have unprecedented access to lifesaving capabilities.

However, with the litany of available options, making the proper prescription decisions has only become more challenging, especially as the one-size-fits-all approach to writing scripts has been deemed ineffective in properly addressing patient needs. At Captiva Lab, we are dedicated to helping medical care providers make the best possible choices. With pharmacogenomics testing, we can help you design a custom treatment plan ideal for your patients.

What is Pharmacogenomics?

Pharmacogenomics refers to the practice of testing biological information to determine the right medication and right dosage for your patients. Also known as genetic pharmacology, gene site testing, PGx, or pharmacogenetics, we are able to help you understand how and why medications will affect your patients, ensuring you make an educated decision in the course of providing care.

The idea that medications do not affect all patients equally is not new, but historically, choosing the right medication resulted in a trial and error approach to medicine. With PGx, it’s now possible to identify the genetic factors that may impact how and why particular medications work – and why they don’t. Rather than cycling through several similar medications until you find one that appeals to a patient, we can help you approach care from an educated perspective.

Our services are designed to fully support your role as a care provider, offering testing panels that cover numerous classes of drugs and relevant biomarkers. With our help, you can ensure your patients receive prescriptions tailored to their unique physiology.

How Pharmacogenomic Testing Works

Pharmacogenomic testing targets particular biomarkers that pertain to a specific class of medication. In doing so, it is possible to determine areas in which drugs are most likely to be effective.

When medications are consumed, their components are metabolized by enzymes throughout the body that are regulated by metabolic pathways. In theory, these pathways would function in the same way in all humans, but genetic differences can create subtle changes that alter how these pathways work. For this reason, a medication that works for one person may have radically different effects on another. Our PGx testing highlights these difference, helping to hone in on what will work best, why it will work, and in what doses.

Please note that genetic pharmacology does not screen for medication conditions; it simply tests for genetic markers that may impact how medications respond within a patient’s body.

The Importance of Pharmacogenomics

Medicine is a science, but the differences in the human genome often make providing care part medical knowledge and part best guesswork. Pharmacogenomics can bridge this gap, helping doctors to better take a scientific approach to medication prescription and management. Without it, it’s possible to spend months or even years cycling through medications, looking for the right fit. This can be stressful, uncomfortable, and even potentially dangerous for patients.

Genetic components can account for anywhere between 20% and 95% of patient variability. In spite of this, roughly 4 billion prescriptions are filled in the U.S. each year, and almost none take into account patient genetic makeup to avoid adverse drug reactions. Further, 3% to 7% of hospital admissions are caused by these kinds of reactions, indicating a serious issue in need of attention. Pharmacogenomics can be extremely effective in addressing these shortcomings, providing a solid starting place for prescription regimens.

Pharmacogenomics can offer countless benefits to your practice and your patients, including:

  • A personalized approach to medicine that improves odds that a treatment will effectively meet patient needs
  • Safer prescriptions that reduce the risk of adverse drug reactions
  • Single tests; genetics don’t change over time, so no testing will be required in the future
  • Expedited patient care; no need for ongoing prescription sampling
  • Decreased cost of overall care

Types of Pharmacogenomic Panels

In order to address as many drug categories as possible, we offer numerous specific and comprehensive panels to best target your patients’ needs.

Psych Panel

Psychiatric Medication Testing

Our psychiatric genetic testing panels are ideal for mood stabilizers, antidepressants, and anti-anxiety drugs, influencing the prescription of over two dozen medications.

Genes Tested: ANKK1, DRD2, CYP1A2, CYP2D6, MTHFR

Pain Panel

Pain Medication Testing

Some pain management drugs are more effective than others. The biomarkers tested in this panel address the efficacy of both Codeine and Tramadol.

Genes Tested: COMT, CYP2B6, CYP2C19, CYP2D6, and OPRM1

Neuro Panel

Neurological Medication Testing

Neuro panels from Captiva Lab explore genes that can impact the efficacy of neurological medication therapies, including anti-seizure, sedative, antidepressant, and dementia drugs.

Genes Tested: CYB5RS, CYP2C19, CYP2C9, CYP2D6

Gastro Panel

Gastrointestinal Medication Testing

Due to the harsh effects of many medications on the digestive systems, GI testing can be extremely important for patients. This panel can influence the prescription of proton-pump inhibitors and gut motility stimulators.

Genes Tested: CYB5RS, CYP2C19

Comp Panel

Comprehensive Testing

For patients who have multiple concerns, comprehensive testing can lay a solid foundation for prescription use, both today and in the future.

Genes Tested: ANKK1, DRD2, APOE, COMT, CYP1A2, CYP2B6, CYP2C19, CYP2C9, CYP2D6, CYP3A4, CYP3A5, Factor II, Factor V Leiden, MTHFR, OPRM1, SLCO1B1, VKORC1

Our Testing Method

Our methodology involves four simple steps designed to streamline the testing process. While testing duration will vary based on the tests requested and the speed with which samples are obtained, we attempt to have results available within one to three business days.

Sample Collection

In order to test patient biomarkers, we will need access to a small biological sample. Our testing procedure utilizes a minimally invasive cheek swab. Through the oral fluid (saliva) collection process, we are able to obtain all of the genetic information necessary for our testing. Please ensure all samples are properly packaged to eliminate the possibility of contamination.

Requisition Form Completion

With your sample, you will need to provide requisition forms that outline your name, practice information, and licensure, patient information, and the test results you would like to receive. We also require information about the reasons behind testing and patient insurance details.

Sample Testing

After we receive completed paperwork and samples, we will immediately begin genetic testing for medication efficacy. We utilize cutting-edge technology to ensure the most accurate results possible. We understand that speed is often of the essence when it comes to patient care, so we will work diligently to provide your results as quickly as we can.

Results Reporting

As soon as our laboratory testing is complete, we will provide a full lab report with all relevant information. Our results will include the specific details of genetic screening, as well as an explanation of what our findings mean for your patient and the medications you are considering. If you have questions about the report you receive, please feel free to contact a member of our customer support team.

If you are seeking a better way to address the unique needs of your patient population, Captiva Lab is here to serve as a world-class resource. We aren’t simple a testing center; we’re prepared to be your partner, providing the support you need to best prescribe medications that will be effective for those you treat. Please contact us today to learn more about what we have to offer.

Sources

  • https://www.aafp.org/afp/2008/0601/p1553.html
  • https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3299179/

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